- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites small business grant applications to use genomic, proteomic, and/or metabolomic technologies to identify molecular fingerprints as novel biomarkers for alcohol exposure and alcohol induced organ damage. Since the development of alcohol-related diseases is a complex multi-step process involving many biological pathways as well as environmental factors, NIAAA is especially interested in the pattern-based molecular fingerprints which consist of multiple genes, RNAs, proteins, metabolites, or combination of them for novel biomarkers with high sensitivity, specificity, and accuracy. NIAAA is also interested in research applications to develop or improve the technologies or methodologies in these areas that would benefit the biomarker discovery for alcohol-induced organ damage. Projects that bring together investigators from diverse scientific disciplines or from both alcohol and non-al!
cohol fields are encouraged. The ultimate goal of the genomic, proteomic, and metabolomic studies in alcohol research is to decipher the interconnecting networks of genes, proteins, and metabolites in order to understand the information flow leading to alcohol use disorders and develop clinical interventions for these diseases.
- NIAAA intends to commit up to $2 million for FY2006.
- Approximately 3 to 6 awards will be made in response to this RFA.
- The grant mechanisms STTR (R41/R42) and SBIR (R43/R44) will be used .
- Eligible institutions include only U.S. small business concerns.
- Eligible principal investigators: On an SBIR application, the principal investigator must have his/her primary employment (more than 50%) with the small business at the time of award and for the duration of the project. The PI on an STTR application may be employed with the small business concern or the participating non-profit research institution as long as s/he has a formal appointment with or commitment to the applicant small business concern, which is characterized by an official relationship between the small business concern and that individual.
- Multiple applications with different research foci by each applicant are allowed, but not encouraged.
- Application submission instructions can be found in the SBIR/STTR Omnibus Solicitation available from the NIH Small Business Funding website http://grants.nih.gov/grants/funding/sbir.htm.
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088
- Initial merit review will be convened by the Office of Extramural Activities at NIAAA
This funding opportunity will utilize the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) mechanisms, but will be run in parallel with an RFA of identical scientific scope (RFA-AA-06-002) that will utilize the traditional research project grant (R01) or the exploratory/developmental (R21) grant mechanism.
Who can apply:
Private Institutions Of Higher Education
Small Business (Less Than 500 Employees
Eligible functional categories:
Alcohol Research Programs
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